You need to say what you mean. There are several places on an AD, where buffering could apply, but I'd suspect the answer is 'no' to all of them.
On the MCP3208, the analog input is unbuffered. An op-amp is needed if the source is not low impedance. Then there is a 'sample and hold' during the actual taking of a reading (the second place where buffering can apply). Then the reading is sent out the SPI port, and is latched during the transmission (but not specifically 'buffered' as such, there is a simgle output latch used for all the SPI transfers). So there is a form of output buffering, but no register that can be accessed other than as part of the sample process.
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